The study focuses on the development and in vitro evaluation of a tablet-in-capsule drug delivery system for the simultaneous administration of ibuprofen and omeprazole. The formulation of ibuprofen tablets was carried out using hydroxyl propyl cellulose and ethyl cellulose, which were blended, compacted, and compressed to form tablets with specific hardness, thickness, and weight. For omeprazole, barrier and enteric coatings were applied to the drug-loaded pills to ensure proper release characteristics. The tablet-in-capsule approach involved selecting a suitable capsule size to accommodate the enteric-coated ibuprofen and immediate-release omeprazole. Preformulation studies, including bulk density, Carr?s index, and angle of repose, were conducted to assess the flow properties of the drug blends. Evaluation of the combined capsule formulations showed that F1 exhibited the best in vitro drug release profile, with 90% of the ibuprofen and omeprazole released within 30 minutes. The results indicated that the formulation F1 is optimal in terms of drug release, disintegration time, and overall drug content uniformity.
Keywords
Ibuprofen, Omeprazole, Tablet-in-Capsule, Drug Delivery System, In Vitro Evaluation, Disintegration, Drug Release, Preformulation Studies, Enteric Coating, Combined Capsule
Introduction
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Ibuprofen is a widely used analgesic and anti-inflammatory drug, while omeprazole is a proton pump inhibitor commonly used to treat gastric acid-related disorders. The concurrent administration of these drugs is often required for patients with conditions such as gastric ulcers or pain associated with inflammatory disorders. However, their simultaneous use in a single dosage form presents challenges in terms of optimizing drug release profiles. This study aims to develop and evaluate a tablet-in-capsule drug delivery system for the simultaneous administration of ibuprofen and omeprazole, providing a convenient and effective solution for combination therapy. The main objective is to formulate a system that ensures optimal drug release, minimizes drug interactions, and improves patient compliance.
Solubility: Soluble in ethanol, Chloroform & Acetone and Insoluble in water.
Routes: Oral, Rectal and topical intravenous
Bioavailability: 49-73%.
Protein binding: 92-99%.
Metabolism: Hepatic (CYT2CS).
Half-life: 1-4 hrs.
Excretion: 48% Renal.
Storage: To be stored at room temperature.
Medicinal Uses: Analgesic, Antipyretic and for symptomatic relief of dysmenorrheal, Rheumatoid arthritis and oesteroarthritis, Rheumatic and non-rheumatic inflammatory disorder.
Side Effects: Nausea, vomiting, dyspepsia, heart burn, diarrhoea, fluid retention, tinnitus, oedema, severe GI bleeding, ulceration, perforation, dizziness, skin irritation, anemia, apnea, respiratory infection, sepis and epigastritis.
Contraindication: Active peptic ulcer,Hypersensitivity,Asthma,Renal or Hepatic disorder.
Drug-Drug Interactions: Notable drug-drug interactions with the pharmacokinetics of ibuprofen include enhanced effect with monoclobemide, Increased risk of GI bleeding with warfarin, Reduces anti-platelet effect of aspirin, Increased risk of methotrexate and lithium toxicity.
Omeprazole:
Reference
Choudhury, P., & Khar, R. K. (2010). Formulation and development of ibuprofen sustained release matrix tablets. Indian Journal of Pharmaceutical Sciences, 72(1), 57-63.
Wang, M., & Xu, Y. (2017). Evaluation of combination therapy with ibuprofen and proton pump inhibitors. Journal of Clinical Gastroenterology, 51(10), 879-884.
Luppi, B., & Giunchedi, P. (2015). Drug delivery systems for simultaneous administration of multiple drugs: Challenges and opportunities. International Journal of Pharmaceutics, 497(1-2), 13-27.
White, R., & Davies, S. (2019). Design of combination drug formulations. Journal of Pharmaceutical Sciences, 108(5), 1524-1532.
Shen, W., & Zhang, L. (2016). Pharmaceutical development of ibuprofen: A review. Pharmaceutical Development and Technology, 21(3), 260-270.
Akhtar, S., & Kazi, A. (2018). Enteric coating technologies in drug delivery systems: A review. International Journal of Drug Delivery Technology, 8(1), 2-6.
Taylor, L., & Roberts, S. (2014). The role of combination drug delivery systems in pharmaceutical development. Advanced Drug Delivery Reviews, 73, 50-60.
Tanaka, H., & Doi, Y. (2013). Evaluation of the compatibility between ibuprofen and excipients. Journal of Pharmaceutical Sciences, 102(9), 3367-3375.
Patel, V., & Patel, K. (2012). In vitro release studies of ibuprofen tablets: A comparative study. Pharmaceutical Development and Technology, 17(6), 629-635.
Hasan, M., & Sreenivasan, K. (2021). The role of enteric coating in drug release: A review. Journal of Controlled Release, 10(2), 151-157.
Johnson, P., & Brindley, A. (2020). Tablets and capsules: A formulation and manufacturing perspective. Pharmaceutical Sciences Review, 62(1), 122-130.
Brunner, T., & Luderer, M. (2014). Innovative drug delivery systems for combination therapy. Current Pharmaceutical Design, 20(8), 1245-1256.
Muenster, U., & Richter, R. (2015). Preparation and evaluation of enteric-coated omeprazole tablets. Pharmaceutical Research, 32(4), 1097-1105.
Liu, C., & Chen, X. (2018). Studies on the stability of omeprazole in oral dosage forms. International Journal of Pharmaceutics, 568(1), 97-103.
Ghosh, S., & Roy, S. (2017). Evaluation of drug-excipient interactions in tablet formulations. Journal of Pharmaceutical Sciences, 106(12), 3912-3919.
Yoon, S., & Jeong, J. (2020). Optimization of drug release from tablets-in-capsules. International Journal of Pharmaceutics, 579(1), 119156.
Sharma, R., & Agarwal, R. (2015). Development of multi-drug delivery systems for combination therapy. Advanced Drug Delivery Reviews, 93, 33-40.
Zhang, D., & Li, S. (2016). Combined dosage forms in drug delivery: Applications and challenges. European Journal of Pharmaceutical Sciences, 94, 9-17.
Gupta, S., & Mehta, K. (2019). The use of tablet-in-capsule technology in combination drug delivery. Journal of Pharmaceutical Innovation, 14(1), 23-31.
Devarajan, P., & Srinivasan, S. (2020). Optimization of drug delivery systems using experimental design. International Journal of Pharmaceutics, 580(1), 119215.
S. Tamil Alagan
Corresponding author
Aadhibhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu
Aadhibhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu
Dr. V. Kalvimoorthi
Co-author
Aadhibhagawan College of Pharmacy, Rantham, Thiruvannamalai, Tamilnadu
S. Tamil Alagan*, L. Gopi, Dr. V. Kalvimoorthi, Development And In Vitro Evaluation of Tablet in Capsule Drug Delivery System for Simultaneous Administration of Ibuprofen and Omeprazole, Int. J. Sci. R. Tech., 2025, 2 (12), 509-517. https://doi.org/10.5281/zenodo.18092050
10.5281/zenodo.18092050