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1Research Scholar, Department of Pharmaceutics, Dr. Babasaheb Ambedkar Technological University, Pune, Maharashtra, India-412216.
2Assistant Professor, Department of Quality Assurance Techniques, Delight College of Pharmacy, Koregaon Bhima, Pune, Maharashtra, India-412216.
3Assistant Professor, Department of Pharmaceutics, Delight College of Pharmacy, Koregaon Bhima, Pune, Maharashtra, India-412216
The increasing prevalence of diabetes has prompted the search for alternative therapeutic strategies to manage the condition effectively. Moringa oleifera, known for its medicinal properties, has shown potential in regulating blood sugar levels. This study focuses on the formulation and evaluation of moringa-based tablets intended for diabetes management. Moringa powder was incorporated into tablet formulations using various excipients, and the tablets were subjected to a series of physicochemical tests, including hardness, friability, disintegration time, and drug content uniformity. In vitro release studies were conducted to determine the drug release profile. The pharmacological efficacy of the formulated tablets was assessed using in vivo models to evaluate their effect on blood glucose levels. The results demonstrated that the moringa tablets exhibited favorable physicochemical properties, with consistent drug release patterns and significant hypoglycemic effects. The findings suggest that moringa tablets could be a promising natural alternative for the management of diabetes, offering an accessible and affordable therapeutic option for diabetic patients. Further clinical studies are recommended to confirm the long-term safety and efficacy of these tablets.
Moringa oleifera is a medicinal plant that has gained a lot of interest for its diverse biological properties. Reviewed evidence indicates the biological capabilities of this plant expand to protecting against complications linked with heart disease, cancer, fatty liver, and diabetes mellitus1. For example, a previously published review supported the beneficial effects of the leaves of the Moringa oleifera in improving blood glucose control in experimental models of diabetes. Notably, this review indicated draw backs such as the limited number of studies that have reported on the potential beneficial effects of this plant, including the fact that summarized literature was mainly conducted in animals, through in vitro and in vivo preclinical models2. Nevertheless, while such information already affirms the hypoglycaemic potential of this medicinal plant, data regarding the prominent biochemical mechanisms implicated in the antidiabetic effects of Moringa oleifera have not been critically reviewed. Recently, Louisa and others supported the potential benefits of Moringa oleifera in cardiovascular or metabolic disorders, mainly by ameliorating the undesired pro-inflammatory response and inhibiting oxidative stress by mediating molecular mechanisms such as hindering nuclear factor kappa B (NF-κB) translocation or enhancing the antioxidant response of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) in different preclinical models3. Thus, there is a need to better understand such intracellular responses of Moringa oleifera within a setting of diabetes or in related metabolic complications. The current study provides a brief overview on Moringa oleifera as medicinal plant, followed by its therapeutic mechanisms in controlling diverse diabetic complications4.
Drug Profile:
Sandip Bhogal*, Vishal Madankar, Sohel Shaikh, Anil Panchal, Formulation and Evaluation of Moringa Tablets for Diabetes Management, Int. J. Sci. R. Tech., 2025, 2 (5), 05-15. https://doi.org/10.5281/zenodo.15315163
10.5281/zenodo.15315163